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Cytochrome b shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

机译：细胞色素b将细胞色素P450 1A1和1A2的抗癌药玫瑰树碱的氧化作用从脱毒转变为活化，从而调节其药理作用

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International audience

机译：国际观众

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Kotrbová, Věra; Mrázová, Barbora; Moserová, Michaela; Martínek, Václav; Hodek, Petr; Hudeček, Jiří; Frei, Eva; Stiborová, Marie;
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年度 2011
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正文语种 en
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1. Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy. [J] . Kotrbova V, Mrazova B, Moserova M, Biochemical Pharmacology . 2011 ,第6期

机译：细胞色素b（5）将抗癌药玫瑰树碱的氧化作用从细胞色素P450 1A1和1A2脱毒转变为活化，从而调节其药理作用。
2. The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b5 and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and Lung [J] . Iveta Vranová, Michaela Moserová, Petr Hodek, International Journal of Electrochemical Science . 2013 ,第2期

机译：玫瑰树碱抗癌药诱导大鼠肝，肾和肺细胞色素P450 1A1、1A2和3A，细胞色素b5和NADPH：细胞色素P450氧化还原酶
3. The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism. [J] . Aimova D, Svobodova L, Kotrbova V, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2007 ,第10期

机译：抗癌药玫瑰树碱是大鼠细胞色素P450 1A1和1A2的有效诱导剂，从而调节其自身的新陈代谢。
4. Remarked properties of human cytochrome P450 1A2 and 3A5 in function and cooperativity for drug development [C] . Yamazaki Hiroshi International Conference on Cytochrome P450 . 2009

机译：探讨人细胞色素P450 1A2和3A5在药物发育功能和合作中的性质
5. Electrochemiluminescent arrays utilizing layer-by-layer films of cytochrome P450/DNA/ruthenuim polymer for drug toxicity screening & unraveling direct electrochemistry of cytochrome P450s. [D] . Krishnan, Sadagopan. 2010

机译：利用细胞色素P450 / DNA /钌聚合物的逐层薄膜的电化学发光阵列，用于药物毒性筛选和揭示细胞色素P450的直接电化学。
6. The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes [O] . Marie Stiborová, Věra Černá, Michaela Moserová, 2015

机译：细胞色素P450激活的抗癌药玫瑰树碱介导DNA损伤确定其药理效率：对大鼠肝细胞色素P450还原酶无效（HRN™）小鼠和纯酶的研究
7. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies:Studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes [O] . Stiborová, Marie, Černá, Věra, Moserová, Michaela, 2015

机译：细胞色素P450激活的抗癌药物玫瑰树碱介导DNA损伤，从而确定其药理效率：大鼠，肝细胞色素P450还原酶无效（HRN™）小鼠和纯酶的研究

Cytochrome b shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

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